CAS No.: | 920509-32-6 |
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Formula: | C17h12cl2n6o4 |
Type: | Synthesis Material Intermediates |
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Resmetirom
Resmetirom; CS-2429; VIA3196; MGL-3196; VIA-3196; Resmetirom(MGL-3196); MGL-3196(Resmetirom); Resmetirom, 10 mM in DMSO; Resmetirom (MGL-3196,VIA-3196); MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196
Resmetirom is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50 = 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure.
Chemical Name | Resmetirom |
CAS | 920509-32-6 |
Molecular Formula | C17H12Cl2N6O4 |
Molecular Weight | 435.22 |
Appearance | white powder |
Color | white |
Brand Name | Megawide |
Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-beta agonist. It works by blocking the formation of fat in the liver and can be used to treat non-alcoholic steatohepatitis (NASH).
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