Vonoprazan Fumarate CAS 1260141-27-2 for Acid-Resistant Drugs

• CAS No.: 1260141-27-2
• Formula: C21h20fn3o6s
• EINECS: 250-635-4
• Model NO.: 1260141-27-2
• Type: Synthesis Material Intermediates
• Appearance: Crystal
• Quality: Industrial
• Colour: White
• From: Powder
• Mf: C21h20fn3o6s
• Solubility: Insoluble in H2O
• MW: 461.4634032
• Transport Package: 25 Kg Paper Bag or as The Request of Customer.
• Trademark: megawide
• Origin: China
• Production Capacity: 10000 Mt/Year

Product Description

 

Product Name

Vonoprazan fumarate

Synonyms

Vonoprazan FuMarate; Vonaprazan; 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan); Vonaprazan(TAK-438);Vonoprazon Fumarate; Vonoprazan fumarate(TAK-438); vonoprazan(tak-438)1260141-27-2;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate;1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine,(E)-4-oxopent-2-enoic acid;AK-438

Product Description

Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H⁺/K⁺ ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na⁺/K⁺ ATPase activity when used at a concentration of 10 μM. It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5) conditions with IC₅₀ values of 19 and 28 nM, respectively. In vivo, vonoprazan (1, 2, and 4 mg/kg) inhibits histamine-stimulated acid secretion in a dose-dependent manner in rats, with complete inhibition when administered at a dose of 4 mg/kg. It also inhibits acid secretion for more than 48 hours in dogs when administered at doses ranging from 0.1 to 1 mg/kg.

 

Product Parameters

 

Chemical Name	Vonoprazan fumarate
CAS	1260141-27-2
EINECS	250-635-4
Molecular Formula	C21H20FN3O6S
Molecular Weight	461.4634032
Appearance	white powder
Color	white
Brand Name	Megawide

Applications

Vonoprazan Fumarate is a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

Packaging & Shipping

Packaging Detail: 25 Kg Paper Bag or as The Request of Customer.
Delivery Detail:

 

Company Profile

Zhangjiagang Free Trade Zone Megawide Chemical Technology Co., Ltd. is professionally engaged in the research, manufacture, and marketing of pine chemicals, fine chemical products.
 
The series are well accepted by clients in flavors, fragrances, personal cares, adhesives, coatings, inks, detergents, pigments, dyes, rubbers, plastics, agrichemicals, medicines, electronics, surfactants, UV, oil fields, textiles, asphalts, mining flotation, metallurgicals, petrochemicals etc.